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Peer-reviewed publications

D. S. Mahrhauser, C. Fischer, C. Valenta. Double emulsions based on silicone-fluorocarbon-water and their skin penetration. Int. J. Pharm. 2016, 498, 130-133

D. S. Mahrhauser, C. Nagelreiter, S. Gehrig, A. Geyer, M. Ogris, K. Kwizda, C. Valenta. Assessment of Raman spectroscopy as a fast and non invasive method for total stratum corneum thickness determination of pig skin. Int. J. Pharm. 2015, 495, 482-484

M. Hoppel, M. Caneri, O. Glatter, C. Valenta. Self-assembled nanostructured aqueous dispersions as dermal delivery systems. Int. J. Pharm. 2015, 495, 459-462

C. Nagelreiter, D. Mahrhauser, K. Wiatschka, S. Skipiol, C. Valenta. Importance of a suitable working protocol for tape stripping experiments on porcine ear skin: Influence of lipophilic formulations and strip adhesion impairment. Int. J. Pharm. 2015, 491, 162-169

D. S. Mahrhauser, H. Kählig, E. Partyka-Jankowska, H. Peterlik, L. Binder, K. Kwizda, C. Valenta. Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid. Int. J. Pharm. 2015, 490, 292-297

D. S. Mahrhauser, G. Reznicek, H. Kotisch, M. Brandstetter, C. Nagelreiter, K. Kwizda, C. Valenta. Semi-solid fluorinated-DPPC liposomes: morphological, rheological and thermic properties as well as examination of the influence of a model drug on their skin permeation. Int. J. Pharm. 2015, 486, 350-355

M. Hoppel, G. Reznicek, H. Kählig, H. Kotisch, G. P. Resch, C. Valenta: Topical delivery of acetyl hexapeptide-8 from different emulsions: Influence of emulsion composition and internal structure. Eur. J. Pharm. Sci., 2015, 68, 27-35

M. Hoppel, S. Juric, H. Ettl, C. Valenta: Effect of monoacyl-phosphatidyl content on the formation of microemulsions and the dermal delivery of flufenamic acid. Int. J. Pharm., 2015, 479, 70-76

M. Hoppel, S. Juric, G. Reznicek, M. Wirth, C. Valenta: Multiple W/O/W emulsions as dermal peptide delivery systems. J. Drug Delivery Sci. Tech., 2015, 25, 16-22

D. Mahrhauser, C. Nagelreiter, J. Skipiol, C. Valenta. Influence of a multiple emulsion, liposomes and a microemulsion gel on sebum, skin hydration and TEWL. Int. J. Cosmetic Sci., 2015, 37, 181-186

M. Hoppel, E. Holper, D. Baurecht, C. Valenta: Monitoring the distribution of surfactants in the strateum corneum by combined ATR-FTIR and tape stripping experiments. Skin Pharm. Phys., 2015, 28, 167-175

M. Hoppel, H. Ettl, E. Holper, C. Valenta: Influence of the composition of monoacyl phosphatidylcholine based microemulsions on the dermal delivery of flufenamic acid. Int. J. Pharm. 2014, 475, 156-162

D. Mahrhauser, M. Hoppel, J. Schöll, L. Binder, H. Kählig, C. Valenta: Simultaneous analysis of skin penetration of surfactant and active drug from fluorosurfactant-based microemulsions. Eur. J. Pharm. Biopharm. 2014, 88, 34-39

M. Hoppel, D. Baurecht, E. Holper, D. Mahrhauser, C. Valenta: Validation of the combined ATR-FTIR/tape stripping technique for monitoring the distribution of surfactants in the strateum corneum. Int. J. Pharm. 2014, 472, 88-93

M. Hoppel, D. Mahrhauser, C. Stallinger, F. Wagner, M. Wirth, C. Valenta: Natural polymer-stabilised multiple W/O/W emulsions: A novel dermal drug delivery system for 5-fluorouracil. J. Pharm. Pharmacol. 2014, 66, 658-667

V. Klang, C. Valenta, N. B. Matsko: Analytical electron microscopy for characterization of fluid or semi-solid multiphase systems containing nanoparticulate material. Pharmaceutics 2013, 5, 115-126

J.C. Schwarz, H. Kählig, M. Hoppel, C. Valenta: Application of 19F nuclear magnetic resonance (NMR) spectroscopy in tape stripping experiments with natural microemulsions. J. Phar. Sci. 2013, 102, 2699-2706

J.C. Schwarz, N. Baisaeng, M. Hoppel, M. Löw, C.M. Keck, C. Valenta: Ultra-small NLC for improved dermal delivery of coenzyme Q10. Int. J. Pharm. 2013, 447, 213-217

V. Klang, J.C.Schwarz, S. Haberfeld, O. Xiao, M. Wirth, C. Valenta: Skin integrity testing and monitoring of in vitro tape stripping by capacitance-based sensor imaging. Skin Res. Technol. 2013, 19, e259-72

J.C. Schwarz, E. Pagitsch, C. Valenta: Comparison of ATR-FTIR spectra of porcine vaginal and buccal mucosa with ear skin and penetration analysis of drug and vehicle component into pig ear. Eur. J. Pharm. Sci. 2013, 50, 595-600

J.C. Schwarz, A. Weixelbaum, E. Pagitsch, M. Löw, G.P. Resch, C. Valenta: Nanocarriers for dermal drug delivery: influence of preparation method, carrier type and rheological properties. Int. J. Pharm. 2012, 437, 83-88

J.C. Schwarz, V. Klang, M. Hoppel, D. Mahrhauser, C. Valenta: Natural microemulsions: formulation design and skin interaction. Eur. J. Pharm. Biopharm. 2012, 81, 557-562

J.C. Schwarz, V. Klang, S. Karall, D. Mahrhauser, G.P. Resch, C. Valenta: Optimisation of W/O/W nanoemulsions for the dermal delivery of aciclovir. Int. J. Pharm. 2012, 435, 69-75

J.C. Schwarz, V. Klang, M. Hoppel, C. Valenta: Corneocyte quantification by NIR densitometry and UV/Vis spectroscopy for human and porcine skin and the role of skin cleaning procedures. Skin Pharmacol. Physiol. 2012, 25, 142-149

V. Klang, J.C. Schwarz, B. Lenobel, M. Nadj, J. Auböck, M. Wolzt, C. Valenta: In vitro vs. in vivo tape stripping: Validation of the porcine ear model and penetration assessment of novel sucrose stearate emulsions. Eur. J. Pharm. Biopharm. 2012, 80, 604-614

V. Klang, J.C. Schwarz, N. Matsko, E. Rezvani, N. El-Hagin, M. Wirth, C. Valenta: Semi-solid sucrose stearate-based emulsions as dermal drug delivery systems. Special Issue Colloidal Drug Carrier Systems of Pharmaceutics (open access), Pharmaceutics 2011, 3, 275-306

J.C. Schwarz, H. Kählig, N. Matsko, M. Kratzel, M. Husa, C. Valenta: Decrease of liposomal size and retrading effect on fluconazole skin permeation by lysine derivatives. J. Pharm. Sci. 2011, 100, 2911-2919

V. Klang, J.C. Schwarz, A. Hartl, C. Valenta: Facilitating in vitro stripping: application of infrared densitometry for quantification of porcine stratum corneum proteins, Skin Pharmacology and Physiology, 2011, 24, 256-268

 

Oral presentations

C. Valenta: Monoacyl phosphatidylcholine based microemulsions and skin delivery. 4th Symposium on Phospholipids in Pharm. Res., September 2015, Heidelberg,  Germany

M. Hoppel:  Self-assembled nanostructured aqueous dispersions as dermal delivery systems. Barrier function of mammalian skin, Gordon Conference, August 2015, Waterville Valley, USAC.

Nagelreiter:  Electron microscopy in topical drug delivery and cosmetics. Advanced Electron Microscopy, ASEM Workshop 2015, Graz, Austria

C. Nagelreiter: Importance of a suitable working protocol in tape stripping experiments. 14th Annual Meeting of Skin Forum,September 2014, Prague, Czech Republic

M. Hoppel, D. Mahrhauser, G. Reznicek, C. Valenta: Influence of the vehicle type on the in-vitro skin permeation of acetyl hexapeptide-8. CRS Annual Meeting, July 2014, Chicago, USA

M. Hoppel, J.C. Schwarz, H. Kählig, C. Valenta: Application of quantitative 19F nuclear magnetic resonance (NMR) spectroscopy in tape stripping experiments with natural microemulsions. 13th Annual Meeting of Skin Forum, June 2013, London, UK

C. Valenta: Biophysical methods: the key in formulation design. 13th Annual Meeting of Skin Forum, June 2013, London, UK

J.C. Schwarz: Kolloidale Arzneiabgabesysteme zur dermalen Applikation: Entwicklung und Optimierung. Evaluation Symposium, 30.5.2012, Vienna

H. Kählig: NMR-Methoden zur Untersuchung von kolloidalen Systemen und Quantifizierung mittels 19F-NMR. Evaluation Symposium, 30.5.2012, Vienna

C. Valenta: Charakterisierung von neuen Hautformulierungen durch in vivo und in vitro Studien. Evaluation Symposium, 30.5.2012, Vienna

J.C. Schwarz, V. Klang: In vitro skin penetration studies on the porcine ear model for investigation of novel dermal and cosmetic formulations. Österreichische Lebensmittelchemiker Tage, April 2012, Linz, Austria

C. Valenta: Charakterisierung und Stabilitätsprüfung von Nanoemulsionen mittels dynamischer Laserlichtstreuung und Elektronenmikroskopie. 16th Annual meeting of the Society for Dermopharmacy, March 2012, Berlin, Germany

J.C. Schwarz: 19F NMR for quantification in tape stripping experiments. 16th Annual meeting of the Society for Dermopharmacy, March 2012, Berlin, Germany

C. Valenta: Aktuelle Forschungsergebnisse: in vivo / in vitro Korrelation. University Day by Vichy/L'Oreal, February 2012, Vienna, Austria

J.C. Schwarz: Nanocarriers for dermal drug delivery: multiple W/O/W nanoemulsions for topical application of aciclovir. Joint meeting of the Austrian and German pharmaceutical societies, September 2011, Innsbruck, Austria

H. Kählig: NMR an der Universität Wien im Institut für Organische Chemie. 1. Österreichischer NMR-Workshop der GÖCH, February 2011, Vienna, Austria

M. Husa et al.: NMR Studies of Liposomes as Drug Carrier Systems. 25th NMR Valtice (Central European NMR Meeting), April 2010, Valtice, Czech Republic

 

Poster presentations

A. Pany, A. Ramic, C. Valenta: Improving skin friendliness of microemulsions: Formulations based on natural surfactants with a reduced content of co-solvent. Galenius Workshop, November 2016, Berlin, Germany

M. Wolf, L. Binder, M. Halper, R. Üribyl, C. Valenta: Skin penetration of liposomes investigazed by combined ATR-FTIR and tape stripping as well as characterization of liposomes by Raman spectroscopy. Galenius Workshop, November 2016, Berlin, Germany

L. Binder, L. Gruber,C. Valenta: Confocal Raman spectroscopy: In vivo measurements of physiological skin parameters. Annual meeting of Skin Forum, June 2016, London, UK

M. Wolf, M. Halper, C. Valenta: Monoacyl Phosphaditylcholin: analysis of skin penetration profiles by combined ATR-FTIR and tape stripping experiments. Annual meeting of Skin Forum, June 2016, London, UK

M. Wolf, M. Hoppel, C. Stix, C. Valenta: Nanostructured Lipid carriers (NLCs) for dermal delivery. 4th Symposium on Phospholipids in Pharm. Res., September 2015, Heidelberg, Germany

M. Hoppel, M. Wolf, C. Valenta: Skin penetration of phospholipids investigated by combined ATR-FTIR and tape stripping experiments. 4th Symposium on Phospholipids in Pharm. Res., September 2015, Heidelberg, Germany

D. S. Mahrhauser, G. Reznicek, S. Gehrig, A. Geyer , R. Kieweler, C. Valenta. Simultaneous determination of drug and vehicle penetration from F-DPPC liposomes into porcine skin layers. Gordon Research Conference: Barrier Function of Mammalian Skin, August 2015, Waterville Valley, USA

M. Hoppel, M. Caneri, O. Glatter, C. Valenta. Self-assembled nanostructured aqueous dispersions as dermal delivery systems. Gordon Research Conference: Barrier Function of Mammalian Skin, August 2015, Waterville Valley, USA

M. Hoppel, K. Kwizda, D. Baurecht, C. Valenta. The effect of a damaged skin barrier on percutaneous absorption of SDS and skin hydration investigated by confocal Raman spectroscopy. CRS Annual Meeting, July 2015, Edinburgh, UK 

D. Mahrhauser, H. Kählig, E. Partyka Jankowska, K. Kwizda, C. Valenta. Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid. 1st European Conference on Pharmaceutics – Drug Delivery, April 2015, Reims, France

D. Mahrhauser, C. Nagelreiter, M. Hoppel, J. Skipiol, C. Valenta. Estimation of selected skin parameters after treatment with different formulations in vivo. Annual conference of pharmacists, February 2015, Schladming, Austria

C. Nagelreiter, D. Mahrhauser, K. Wlatschka, C. Valenta: Importance of a suitable working protocol in tape stripping experiments. 14th Annual Meeting of Skin Forum,September 2014, Prague, Czech Republic

M. Hoppel, D. Mahrhauser, H. Ettl, E. Holper, C. Valenta:Skin interaction of monoacyl phasphatidylcholine based microemulsions. 14th Annual Meeting of Skin Forum,September 2014, Prague, Czech Republic

D. Mahrhauser, C. Nagelreiter, M. Hoppel, J. Skipiol, C. Valenta:In vivo measurement of physiological skin parameters after treatment with selected formulations. 14th Annual Meeting of Skin Forum,September 2014, Prague, Czech Republic

D. Mahrhauser, J. Schöll, M. Hoppel, H. Kählig, C. Valenta: Investigation of the penetration of vehicle components and active drug from fluorosurfactant-based microemulsions. 18th GD Jahrestagung, April 2014, Berlin, Germany

M. Hoppel, D. Baurecht, E. Holper, D. Mahrhauser, C. Valenta: Monitoring the distribution of anionic surfactants in the stratum corneum by combined ATR-FTIR and tape stripping experiments. 18th GD Jahrestagung, April 2014, Berlin, Germany

M. Hoppel, D. Mahrhauser, D. Baurecht, E. Holper, C. Valenta: Anionic vs natural surfactant: influence on skin barrier properties. 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 2014, Lisbon, Portugal

D. Mahrhauser, M. Hoppel, L. Binder, C. Valenta: Comparison of drug diffusion through two artifical membranes with porcine skin. 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 2014, Lisbon, Portugal

D. Mahrhauser, M. Hoppel, J. Schöll, H. Kählig, C. Valenta: Development of novel microemulsions with fluorinated surfactants and their influence on skin structure. 13th Annual Meeting of Skin Forum, June 2013, London, UK

M. Hoppel, D. Mahrhauser, F. Wagner, H. Kotisch, G.P. Resch, C. Valenta: Development and characterisation of a W/O/W double emulsion based on natural surfactants. 13th Annual Meeting of Skin Forum, June 2013, London, UK

M. Hoppel, D. Mahrhauser, C. Stallinger, M. Wirth, C. Valenta: Stabilisation of a W/O/W multiple emulsion using a natural polymer. 17th Annual Meeting of the Society for Dermopharmacy, March 2013, Mainz, Germany

J.C. Schwarz, A. Weixelbaum, E. Pagitsch, G.P.resch, C. Valenta: Ultrasound-engineered nanocarriers: physicochemical characterisation and skin permeation. 9th Central European Symposium of Pharmaceutical Technology with Focus on Nanopharmaceuticals and Nanomedicine (CESPT), September 2012, Dubrovnik, Croatia

J.C. Schwarz, E. Pagitsch, C. Valenta: Comparative ATR-FTIR analysis of the barrier function of the stratum corneum and vaginal mucosa. 13th Skin Forum, September 2012, Cardiff, UK

J.C. Schwarz, D. Mahrhauser, C. Valenta: Characterisation of the skin penetration of DPPC liposomes by combined tape stripping and ATR-FTIR experiments. 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 2012, Istanbul, Turkey

J.C. Schwarz, V. Klang, D. Mahrhauser, T.M. Wrodnigg, C. Valenta: Influence of novel sugar-amino acid conjugates on skin structure and penetration of flufenamic acid. 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 2012, Istanbul, Turkey

V. Klang, J.C. Schwarz, B. Lenobel, M. Nadja, A. Hartl, J. Auböck, M. Wolzt, C. Valenta: In vitro vs in vivo tape stripping: validation of the porcine ear model. 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 2012, Istanbul, Turkey

J.C. Schwarz, M. Hoppel, H. Kählig, C. Valenta: 19F NMR for drug quantification in tape stripping experiments.  16th Annual meeting of the Society for Dermopharmacy, March 2012, Berlin, Germany (Awarded with the 3rd Poster Prize by the Scientific Committee of the Society for Dermopharmacy)

J.C. Schwarz, V. Klang, S. Karall, S. Haberfeld, C. Valenta: Development of Eudermic W/O/W Nanoemulsions for Delivery of Hydrophilic Drugs. 12th Skin Forum, March 2011, Frankfurt, Germany

V. Klang, J.C. Schwarz, A. Hartl, C. Valenta: Infrared Densitometry for Quantification of Porcine Stratum Corneum Proteins. 12th Skin Forum, March 2011, Frankfurt, Germany

V. Klang, J.C. Schwarz, N. Matsko, N. El-Hagin, M. Wirth, C. Valenta: Semi-Solid Sucrose Stearate-Based Emulsions as Dermal Drug Delivery Systems. 12th Skin Forum, March 2011, Frankfurt, Germany

J. C. Schwarz, M. Kratzel, M. Husa, H. Kählig, C. Valenta: Influence of oligo-peptides on fluconazole – loaded DPPC liposomes: improvement of size, physicochemical stability parameters and skin interaction. 11th Skin Forum, July 2010, Edinburgh, UK

 

PH.D. thesis

D. Mahrhauser: Simultaneous determination of the skin penetration of drug and vehicle compounds by 19F-NMR and assessment of their interaction with the skin by ATR-FTIR spectroscopy. 2015, Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna

M. Hoppel: Development of dispersed drug delivery systems and investigation of their skin penetration by ATR-FTIR spectroscopy. 2015, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

J. C. Scwarz: Formulation design of dermal drug delivery systems. Characterisation by NMR and Investigation of skin interaction by ATR-FTIR. 2012, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

 

Diploma theses

M. Caneri: Investigation of skin absorption and skin interaction by non invasive techniques. 2016, Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna

C. Fischer: Development and characterisation of S/F/W emulsionen and investigation of their influence on the skin penetration of Curcumin, (Diploma thesis. 2016, Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna

C. Stix: Nanostructured Lipid Carriers (NLCs) for dermal delivery, development and stability testing. 2016, Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna

J. Schöll, Microemulsions based on fluorosurfactants for dermal application. 2015, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

K. Wiatschka: Influence of different parameters on Tape stripping experiments and evaluation of fluorinated lipids for liposomes. 2015, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

E. Holper: ATR-FTIR Investigations and conformation change of the barrier function after application of selected surfactants and formulations with surfactants. 2015, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

R. Kieweler: F-DPPC formulations as Drug delivery system and investigation of skin penetration. 2015, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

K. Kwizda: Analysis of the thickness of the stratum corneum of porcine skin and skin penetration of SDS with Raman spectroscopy. 2015,  Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

J. Skipiol: Einfluss ausgewählter wirkstofffreier Formulierungen auf bestimmte Hauteigenschaften und Untersuchung der Wirkstoffdiffusion aus einem Mikroemulsionsgel. 2014, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

L. Binder: Charakterisierung kolloidaler Strukturenverschiedener Öl/Wasser/Tensid-<systeme zur Anwendung an der Haut. 2014, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

F. Wagner: Characterisation of different formulations and interactions with porcine skin by ATR-FTIR. 2013, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

A. Weixelbaum: Nanocarriers for topical application of flufenamic acid: comparison of physical chemical behaviour and skin penetration of nanoemulsions, SLN and NLC. 2013, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

C. Stallinger: Development of W/O/ emulsions by one step emulsification and stability optimization by natural polymers. 2013, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

M. Hoppel: Natural microemulsions based on sugaresters: development, characterisation and skin penetration.2012, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

S. Karall: development of multiple W/O/W nanoemulsions by low energy emulsification for dermal application of hydrophilic drugs. 2012, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

D. Mahrhauser: Entwicklung von Mikroemulsionssystemen und Charakterisierung von Wechselwirkungen mit porciner Haut mittels FTIR. 2011, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

R. Winkler: FTIR-Untersuchungen zur Veränderung des Stratum corneum nach Applikation verschiedener Formulierungen. 2011, Department of Pharmaceutical Technology and Biopharmacy, University of Vienna

M. Husa: Characterisation of Liposomes as Drug-Carrier Systems by High-Resolution NMR-Spectroscopy. 2010, Institute of Organic Chemistry, University of Vienna

 

Press Release

Die Presse, 12.7.2014: "Medikamente die unter die Haut gehen"

Forschungsnewsletter University of Vienna, March, 2014: "Forschung hautnah"

DoktorandInnenzentrum University of Vienna, December 2012: "Julia Schwarz mit Award of Excellence ausgezeichnet"

Die Presse: Dissertation der Woche, 3.11.2012: "Hautheilung: Ganz natürlich und nano"

Faculty Research News June 2012, Faculty of Life Sciences, University of Vienna: "Natürlich hautfreundlich"

Medienportal Uni:View University of Vienna, March 2012: "P.B. Czedik-Eysenberg-Preis für Victoria Klang und Julia Schwarz"

Forschungsnewsletter University of Vienna, April 2010: "Neue Forschungsplattform geht unter die Haut"

Forschungsplattform Characterisation of Drug Involved Mechanisms

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